A: Urbana, Illinois, United States
In 1957 Lejaren Hiller and Leonard Isaacson of the University of Illinois at Urbana-Champaign collaborated on the first significant computer music composition, the Illiac Suite, composed on the University of Illinois ILLIAC I computer.
You can play the music composition at the link below:
The ILLIAC I was the first von Neumann architecture computer built and owned by an American university.