Having obtained permission from both the Venetian Senate and the Pope to become the first publisher of Hebrew books in Venice, from 1519 to 1523 devout Christian Daniel van Bomberghen (Daniel Bomberg) issued the first complete printed edition of the approximately two million word Babylonian Talmud.
Over his 40 year career Bomberg issued 240 editions of books in Hebrew.
"Based on current knowledge of contemporary Venetian printing practices, we can safely speculate that each Bomberg edition of the Talmud was produced in print-runs of approximately 1500 copies, though of course most of them did not find their way into full sets. We do have evidence from a book catalog printed sometime between 1541 and 1543 that a complete set was available for purchase for the price of twenty-two Venetian ducats. This was at a time when one of Bomberg’s typesetters earned somewhere between 2½ and 3 ducats per month. Thus, even when first printed, these volumes were considered expensive and accessible to only the wealthiest of individuals."
"Bibliographers variously surmise that the Bomberg Talmud was normally bound in twelve or fifteen volumes in a standard order, though this is problematic. Among the fourteen known complete sets that survive as sets from the sixteenth-century, in addition to this set two others are bound in six volumes, one in eight volumes, three in nine, one in ten, one in seventeen, one in twenty-two, and only four sets are bound in twelve volumes. Even among those bound in twelve volumes, there is no standard ordering of the tractates in the various volumes" (Mintz & Goldstein, Printing the Talmud from Bomberg to Schottenstein  No. 20).