One of the largest surviving Netherlandish depictions of The Annunciation, the panel painting by Hans Memling preserved in the Metropolitan Museum of Art, is based upon a design by Rogier van der Weyden. The painting is notable for depicting the Virgin Mary reading from what appears to be a small manuscript codex during the very early years of the transition from manuscript to print, from about 1465 to 1475.
". . . this imposing painting may have been the left wing of a triptych commissioned by the Clugny family, whose coat of arms decorates the carpet and window. The composition is based on a design by Rogier van der Weyden. Possibly commissioned before his death in 1464, it was painted by Hans Memling who, technical evidence suggests, was a journeyman in Rogier's workshop before establishing himself in Bruges in 1465" (http://www.metmuseum.org/Collections/search-the-collections/110001941, accessed 10-25-2011).