The Codex Mediceus of Virgil (Vergil) (Florence, Laur. 39.1 + Vatican lat. 3225, f.76), a fifth century manuscript written in rustic capitals, preserved in the Laurentian Library (Biblioteca Medicea Laurentiana) in Florence, with a single leaf preserved in the Vatican Library, contains the Ecologues from VI.48, the Georgics, and the Aeneid. A subscription at the end of the Ecologues records that the manuscript was corrected at Rome by Turcius Rufius Apronianus Asterius, consul in 494. Reynolds states that the manuscript "found its way to Bobbio, and was still there in 1467." Soon thereafter it was taken to the Vatican Library in Rome, and by 1471 it was in the hands of humanist Julius Pomponius Laetus (Pomponio Leto) who wrote emendations in the codex in red ink. The manuscript was first preserved in the Vatican Library, and later purchased by Cosimo de' Medici from the heirs of Cardinal Rodolpho Pio da Carpi, who died in 1564.
In 1741 the Codex Mediceus was first published in print in an extraordinary typographic reproduction, or typographic facsimile, planned and edited by Vatican librarian and philologist Pier Francesco Foggini. The edition, printed by Manniani in Florence, was printed with types imitating the uncial script of the original, in red and black. By combining different sizes of types, the printer was also able to include the annotations and emendations of Asterius and Laetus. The edition began with an engraved vignette that reproduced a fragment of the manuscript in more literal detail.
In Printing Types I (1962, p. 171) Daniel Berkeley Updike commented on this edition as follows:
"A curious piece of Italian typography, very characteristic of the eighteenth century, is an edition of Virgil (P.Vergilii Maronis, Codex Antiquissimus, A Rufio Turcio Aproniano V. C. Distinctus et Emendatus. . . Florentiae. Typis Mannianis), published in 1741 at Florence, and printed by Joseph Manni, a person of scholarly tastes. It is set entirely in old style capitals with a few characters imitating those of an ancient and famous manuscript of Virgil in rustic characters in the Laurentian Library, Florence. The preface exhibits a fairly accurate engraved reproduction of a few lines of the model on which the book was based, and in the text the ingenious introduction of but three specially cut letters give the general effect of a font of 'rustic' type. Thus the work displays that amazing audacity in arriving at a striking effect, notwithstanding inaccurate details and economy of method, which was typical of Italian printing at that time. Issued at a place and period which appears unfavourable to such a venture, and dedicated to lovers of the Fine Arts, it also indicates there has always been a public sufficiently sympathetic to encourage such publications. The volume is enlivened by occasional rubrication which gives it a distinguished air."
Reynolds, Texts and Transmission. A Survey of the Latin Classics (1983) 433.