In 1931 English physician Archibald Garrod, Regius Professor of Medicine at Oxford, issued The Inborn Factors in Disease from Oxford at the Clarendon Press. The result of his continuing researches on what he previously designated as Inborn Errors of Metabolism, Garrod argued that chemical individuality could result in individuals having a predisposition to certain diseases. This concept, which Garrod initially called diathesis, he regarded an an inherited predisposition expressed as chemical individuality in forms more subtle than those so obvious in the inborn errors of metabolism. This view was later much appreciated with the development of recominbant DNA methods to identify inherited genetic defects.
J. Norman (ed) Morton's Medical Bibliography 5th ed (1991) no. 253.2.