Max Perutz Opens Up the Field of Molecular Pathology

In August 1968 Max Perutz opened up "the field of 'molecular pathology,' relating a structural abnormality to a disease" (Aaron Klug, "Max Perutz 1914-2002," Science 295 (2002) 2383). Specifically Perutz showed that hemoglobin molecules collapse into a sickle shape in the blood disorder sickle-cell anemia.

Perutz and Lehmann, H., "Molecular Pathology of Human Hemoglobin," Nature 219 (1968) 902-09.